An Interview With Dr Randall
Many antibiotics are associated with the same exact side effects as alcohol, such as dizziness, nausea, drowsiness and overall stomach upset. Mixing both substances together can cause you to have an increased level of side effects that are much more prominent. Imagine taking an antibiotic that causes you to feel a bit nauseous and then drinking alcohol on top of it. Chances are you would be left feeling very ill as a result. These are definitely things to consider while taking antibiotics. Most antibiotic courses do not last longer than 7 to 10 days so it seems it would be prudent during this time to abstain from drinking alcohol temporarily.
Most evidence for this interaction is based on case-control studies. A large case-control study conducted in the U.S. and Sweden indicated a strong positive association between NSAID or aspirin and alcohol use in increasing risk for an upper GI bleed. The highest incidence of upper GI bleed was in patients who were heavy drinkers (³3 drinks/day) and used aspirin (>325 mg/day) and/or ibuprofen. 26 However, this study did not provide enough information on other NSAIDs, including celecoxib. Nevertheless, the package insert for celecoxib states an increased risk of developing an ulcer or GI bleed when NSAIDs are used with alcohol. 28
Alcohol and antibiotics are in direct competition with each other in terms of the metabolic enzymes the body uses to break them down. Because of this the antibiotics are forced to remain in the person blood stream for a much longer period of time. This offers a marked increase in the chances of side effects occurring as a result of the antibiotics. On the contrary, prolonged use of alcohol seems to stimulate a much higher production of that same metabolic enzyme, meaning the quantity of antibiotics in the body may be reduced significantly, requiring the dosage to be increased.
I ndividuals who drink alcoholic beverages should be aware that simultaneous use of alcohol and medications-both prescribed and over-the-counter-has the potential to cause problems. For example, even very small doses of alcohol probably should not be used with antihistamines and other medications with sedative effects. Individuals who drink larger amounts of alcohol may run into problems when commonly used medications (e.g., acetaminophen) are taken at the same time or even shortly after drinking has stopped. Elderly individuals should be especially careful of these potential problems due to their generally greater reliance on multiple medications and age-related changes in physiology.
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